No contemporary filmmaker has chronicled the messy human experience with the eye and ear of a comedic cultural anthropologist like Judd Apatow. Hits as varied as those he’s directed, like KNOCKED UP and THE 40-YEAR-OLD VIRGIN, and those he’s produced, like BRIDESMAIDS, are all unified by their honest, unflinching, comic look at how complicated it is to grow up in the modern world.

Apatow has also built a history of helping break distinctive new comedy voices into the mainstream, from Seth Rogen to Lena Dunham among many others. Now, in his fifth feature film as a director, Apatow again brings a portrait of an unforgettable character, and a portrayal by a breakout new comedy star, together in TRAINWRECK, written by and starring Amy Schumer (“Inside Amy Schumer”) as a woman who lives her life without apologies, even when maybe she should apologize.

Since she was a little girl, it’s been drilled into Amy’s (Schumer) head by her rascal of a dad (Colin Quinn) that monogamy isn’t realistic. Now a magazine writer, Amy lives by that credo — enjoying what she feels is an uninhibited life free from stifling, boring romantic commitment — but in actuality, she’s kind of in a rut. When she finds herself starting to fall for the subject of the new article she’s writing, a charming and successful sports doctor named Aaron Conners (Bill Hader), Amy starts to wonder if other grown-ups, including this guy who really seems to like her, might be on to something.